Linda B. Buck
| Linda B. Buck | |
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| Born | January 29, 1947 Seattle, Washington |
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| Nationality | American |
| Fields | Biologist |
| Institutions | Fred Hutchinson Cancer Research Center University of Washington, Seattle Howard Hughes Medical Institute Columbia University |
| Alma mater | University of Washington, Seattle |
| Known for | olfactory receptors |
| Notable awards | Nobel Prize in Physiology or Medicine (2004) |
Linda B. Buck, Ph.D., (born January 29, 1947) is an American biologist best known for her work on the olfactory system. She was awarded the 2004 Nobel Prize in Physiology or Medicine, along with Richard Axel, for their work on olfactory receptors.
In their landmark paper published in 1991, Buck and Axel cloned olfactory receptors, showing that they belong to the family of G protein-coupled receptors. By analyzing rat DNA, they estimated that there were approximately one thousand different genes for olfactory receptors in the mammalian genome. This research opened the door to the genetic and molecular analysis of the mechanisms of olfaction. In their later work, Buck and Axel have shown that each olfactory receptor neuron remarkably only expresses one kind of olfactory receptor protein and that the input from all neurons expressing the same receptor is collected by a single dedicated glomerulus of the olfactory bulb.
Born in Seattle, Washington, Buck received her B.S. in psychology and microbiology in 1975 from the University of Washington, Seattle and her Ph.D. in immunology in 1980 from the University of Texas Southwestern Medical Center at Dallas. She did her post-doctoral work at Columbia University under Axel. Her primary research interest is on how pheremones and odors are detected in the nose and interpreted in the brain. However, one of her key publications [1] on this topic independent of Axel was recently retracted for being irreproducible [2]. She is also studying the mechanisms underlying aging and the lifespan of C. elegans [3]. This work was fundamentally questioned by others [4]. She is a Full Member of the Basic Sciences Division at Fred Hutchinson Cancer Research Center, an Affiliate Professor of Physiology and Biophysics at the University of Washington, Seattle and an Investigator of the Howard Hughes Medical Institute. She was inducted into the National Academy of Sciences in 2004.
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Please help improve this section by expanding it. Further information might be found on the talk page. (March 2008) |
- Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 1991;65:175-87. PMID 1840504.
- ^ . PMID 11700549.
- ^ . PMID 18322536.
- ^ . PMID 18033297.
- ^ . PMID 19112515.
- Nobel Citation
- Webpage at the Fred Hutchinson Cancer Research Center
- Webpage at Howard Hughes Medical Institute
- BBC
- Curriculum vitae of Linda Buck
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